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A generic drug meets the same stringent performance and bioequivalence standards set by the U.S. government as the brand name drug. Each generic drug is laboratory-tested to ensure that the same amount of drug will be absorbed into the bloodstream as with the brand-name drug. Since 1984 no generic drug has been approved in the U.S. unless it has been shown to have the same rate and amount of active drug absorbed as the brand-name drug.

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Many of the generic drugs approved by the FDA are manufactured by companies that also make brand-name drugs. Many more generic drugs will become available as brand-name drugs lose their patent protection. More commonly, brand manufacturers are making generic drugs when they lose brand patent protection to compete directly with other generic makers and their branded product.